
Pioneering Computational RNA Drug Discovery
Unlocking RNA’s Therapeutic Potential Through AI-Driven Computational Mastery
Darien Biodiscovery is a virtual CRO specializing in RNA-targeted drug discovery, structure modeling, and gigascale library design – no wet-lab work, no software licenses, just results.
Key Services Overview
RNA-Ligand Interaction Modeling
RNA Structure Prediction
RNA-Focused Chemical Libraries
RNA Therapeutic Optimization
Virtual screening, G-quadruplex targeting, Fragment-based drug design.
Secondary/tertiary modeling, folding dynamics, RNA-protein interfaces.
Gigascale libraries, non-enumerated spaces & generative AI-driven design.
siRNA/ASO, CRISPR guides design, aptamer design & optimization.









Darien Biodiscovery – The Only Focused CRO for Computational RNA Drug Development
Join Hands with Darien – Decoding the New Era of RNA Medicine
Our Key Differentiators
RNA-Centric Expertise
Gigascale Power
Zero Overhead, Full IP
Exclusive focus on RNA targets – from viral elements to lncRNAs.
Screen >10B compounds with proprietary GPU/ML workflows.
No infrastructure costs. You own all data and designs.






Innovative Solutions
Developing advanced software for AI-aided drug design and discovery.
Molecular Modeling
Our molecular modeling services enhance drug discovery through precise simulations and analyses, enabling companies to visualize and optimize potential drug candidates effectively and efficiently in their development processes.
Cheminformatics Services
We provide comprehensive cheminformatics services that support drug discovery efforts, utilizing data analysis and computational techniques to identify promising compounds and streamline the research process for our clients.